EBV-associated perianal Hodgkin's disease in an HIV-positive individual.
Identifieur interne : 001077 ( Main/Exploration ); précédent : 001076; suivant : 001078EBV-associated perianal Hodgkin's disease in an HIV-positive individual.
Auteurs : M. Sapp [Canada] ; B. Perez-Ordonez ; F. Brenneman ; K. Imrie ; I. Morava-Protzner ; M S LimSource :
- American journal of hematology [ 0361-8609 ] ; 2001.
Descripteurs français
- KwdFr :
- Adulte, Cellules de Reed-Sternberg (), Cellules de Reed-Sternberg (virologie), Ghana (ethnologie), Humains, Immunophénotypage, Infections à virus Epstein-Barr (), Infections à virus Epstein-Barr (virologie), Issue fatale, Lymphome lié au SIDA (), Lymphome lié au SIDA (virologie), Maladie de Hodgkin (virologie), Maladie de Hodgkin (étiologie), Mâle, Ontario, Tumeurs de l'anus (virologie), Tumeurs de l'anus (étiologie), Tumeurs du rectum (virologie), Tumeurs du rectum (étiologie).
- MESH :
- ethnologie : Ghana.
- virologie : Cellules de Reed-Sternberg, Infections à virus Epstein-Barr, Lymphome lié au SIDA, Maladie de Hodgkin, Tumeurs de l'anus, Tumeurs du rectum.
- étiologie : Maladie de Hodgkin, Tumeurs de l'anus, Tumeurs du rectum.
- Adulte, Cellules de Reed-Sternberg, Humains, Immunophénotypage, Infections à virus Epstein-Barr, Issue fatale, Lymphome lié au SIDA, Mâle, Ontario.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Anus Neoplasms (etiology), Anus Neoplasms (virology), Epstein-Barr Virus Infections (complications), Epstein-Barr Virus Infections (virology), Fatal Outcome, Ghana (ethnology), Hodgkin Disease (etiology), Hodgkin Disease (virology), Humans, Immunophenotyping, Lymphoma, AIDS-Related (complications), Lymphoma, AIDS-Related (virology), Male, Ontario, Rectal Neoplasms (etiology), Rectal Neoplasms (virology), Reed-Sternberg Cells (chemistry), Reed-Sternberg Cells (virology).
- MESH :
- geographic , ethnology : Ghana.
- chemistry : Reed-Sternberg Cells.
- complications : Epstein-Barr Virus Infections, Lymphoma, AIDS-Related.
- etiology : Anus Neoplasms, Hodgkin Disease, Rectal Neoplasms.
- virology : Anus Neoplasms, Epstein-Barr Virus Infections, Hodgkin Disease, Lymphoma, AIDS-Related, Rectal Neoplasms, Reed-Sternberg Cells.
- Adult, Fatal Outcome, Humans, Immunophenotyping, Male, Ontario.
Abstract
Hodgkin's disease (HD) has a higher incidence in HIV-positive individuals. It tends to occur at extranodal sites, frequently exhibits an unfavorable histological type with large numbers of neoplastic cells, and almost invariably harbors Epstein-Barr Virus (EBV). We describe a case of a 33-year-old HIV-positive man who presented with anal pain from a 4-cm mass in the anorectal canal. He had no B symptoms or peripheral lymphadenopathy. A chest X-ray was within normal limits. A biopsy showed an ulcerated mass composed of a mixed infiltrate of lymphocytes, plasma cells, eosinophils, and Reed-Sternberg (RS) cells positive for CD15 and strongly positive for CD30. They were negative for CD45 and CD20. Numerous RS cells and lymphocytes were positive for EBV RNA using the EBER-1 probe. This highly unusual presentation of HD may reflect the greater incidence of anorectal lymphoma and of extranodal HD in the HIV-positive population.
DOI: 10.1002/1096-8652(200101)66:1<42::AID-AJH1006>3.0.CO;2-V
PubMed: 11426491
Affiliations:
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Le document en format XML
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Sapp</name><affiliation wicri:level="4"><nlm:affiliation>Department of Laboratory Medicine, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Perez Ordonez, B" sort="Perez Ordonez, B" uniqKey="Perez Ordonez B" first="B" last="Perez-Ordonez">B. Perez-Ordonez</name></author><author><name sortKey="Brenneman, F" sort="Brenneman, F" uniqKey="Brenneman F" first="F" last="Brenneman">F. Brenneman</name></author><author><name sortKey="Imrie, K" sort="Imrie, K" uniqKey="Imrie K" first="K" last="Imrie">K. Imrie</name></author><author><name sortKey="Morava Protzner, I" sort="Morava Protzner, I" uniqKey="Morava Protzner I" first="I" last="Morava-Protzner">I. Morava-Protzner</name></author><author><name sortKey="Lim, M S" sort="Lim, M S" uniqKey="Lim M" first="M S" last="Lim">M S Lim</name></author></analytic><series><title level="j">American journal of hematology</title><idno type="ISSN">0361-8609</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anus Neoplasms (etiology)</term><term>Anus Neoplasms (virology)</term><term>Epstein-Barr Virus Infections (complications)</term><term>Epstein-Barr Virus Infections (virology)</term><term>Fatal Outcome</term><term>Ghana (ethnology)</term><term>Hodgkin Disease (etiology)</term><term>Hodgkin Disease (virology)</term><term>Humans</term><term>Immunophenotyping</term><term>Lymphoma, AIDS-Related (complications)</term><term>Lymphoma, AIDS-Related (virology)</term><term>Male</term><term>Ontario</term><term>Rectal Neoplasms (etiology)</term><term>Rectal Neoplasms (virology)</term><term>Reed-Sternberg Cells (chemistry)</term><term>Reed-Sternberg Cells (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Cellules de Reed-Sternberg ()</term><term>Cellules de Reed-Sternberg (virologie)</term><term>Ghana (ethnologie)</term><term>Humains</term><term>Immunophénotypage</term><term>Infections à virus Epstein-Barr ()</term><term>Infections à virus Epstein-Barr (virologie)</term><term>Issue fatale</term><term>Lymphome lié au SIDA ()</term><term>Lymphome lié au SIDA (virologie)</term><term>Maladie de Hodgkin (virologie)</term><term>Maladie de Hodgkin (étiologie)</term><term>Mâle</term><term>Ontario</term><term>Tumeurs de l'anus (virologie)</term><term>Tumeurs de l'anus (étiologie)</term><term>Tumeurs du rectum (virologie)</term><term>Tumeurs du rectum (étiologie)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Reed-Sternberg Cells</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Epstein-Barr Virus Infections</term><term>Lymphoma, AIDS-Related</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Anus Neoplasms</term><term>Hodgkin Disease</term><term>Rectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules de Reed-Sternberg</term><term>Infections à virus Epstein-Barr</term><term>Lymphome lié au SIDA</term><term>Maladie de Hodgkin</term><term>Tumeurs de l'anus</term><term>Tumeurs du rectum</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Anus Neoplasms</term><term>Epstein-Barr Virus Infections</term><term>Hodgkin Disease</term><term>Lymphoma, AIDS-Related</term><term>Rectal Neoplasms</term><term>Reed-Sternberg Cells</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladie de Hodgkin</term><term>Tumeurs de l'anus</term><term>Tumeurs du rectum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Fatal Outcome</term><term>Humans</term><term>Immunophenotyping</term><term>Male</term><term>Ontario</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Cellules de Reed-Sternberg</term><term>Humains</term><term>Immunophénotypage</term><term>Infections à virus Epstein-Barr</term><term>Issue fatale</term><term>Lymphome lié au SIDA</term><term>Mâle</term><term>Ontario</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hodgkin's disease (HD) has a higher incidence in HIV-positive individuals. It tends to occur at extranodal sites, frequently exhibits an unfavorable histological type with large numbers of neoplastic cells, and almost invariably harbors Epstein-Barr Virus (EBV). We describe a case of a 33-year-old HIV-positive man who presented with anal pain from a 4-cm mass in the anorectal canal. He had no B symptoms or peripheral lymphadenopathy. A chest X-ray was within normal limits. A biopsy showed an ulcerated mass composed of a mixed infiltrate of lymphocytes, plasma cells, eosinophils, and Reed-Sternberg (RS) cells positive for CD15 and strongly positive for CD30. They were negative for CD45 and CD20. Numerous RS cells and lymphocytes were positive for EBV RNA using the EBER-1 probe. This highly unusual presentation of HD may reflect the greater incidence of anorectal lymphoma and of extranodal HD in the HIV-positive population.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Brenneman, F" sort="Brenneman, F" uniqKey="Brenneman F" first="F" last="Brenneman">F. Brenneman</name><name sortKey="Imrie, K" sort="Imrie, K" uniqKey="Imrie K" first="K" last="Imrie">K. Imrie</name><name sortKey="Lim, M S" sort="Lim, M S" uniqKey="Lim M" first="M S" last="Lim">M S Lim</name><name sortKey="Morava Protzner, I" sort="Morava Protzner, I" uniqKey="Morava Protzner I" first="I" last="Morava-Protzner">I. Morava-Protzner</name><name sortKey="Perez Ordonez, B" sort="Perez Ordonez, B" uniqKey="Perez Ordonez B" first="B" last="Perez-Ordonez">B. Perez-Ordonez</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Sapp, M" sort="Sapp, M" uniqKey="Sapp M" first="M" last="Sapp">M. Sapp</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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